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Informazioni Personali
Stefano
Amente
Informazioni Didattiche

Stefano Amente, PhD
General Information.

Date and place of birth
: 03 September 1975, Naples, Italy 

Nationality: Italian 

Office Address: Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80I26 Naples, Italy.
e-mail: stamente@unina.it

Educations

2002.
Graduation from the University of the Study of Naples “FEDERICO II” with the highest grade and honours (summa cum laude).

2007. PhD graduation from the University of the Study of Naples “FEDERICO II” in Genetics and Molecular Medicine.

Positions

2006.
Visiting scientist, Institute of Cancer Research, Columbia University, NYC, USA.

2007-2008. Post-doctoral research fellow, AIRC, Italy. 
2008-2010. Award AIRC Triennal Post-doc research fellow, AIRC Naples Oncogenomic Center, Italy
2009. Visiting scientist, Institute of Cancer Research, Columbia University, NYC, USA.

2011. Post-doctoral research, DBSF, University of Naples 'Federico II', Naples, Italy
2011.
Visiting scientist, European Institute of Oncology, IEO, Milan, Italy.

2012-to date.
Researcher in Genetics, University of Naples Federico II

Synopsis of research interest and activity.

- Functional and biochemical characterization of the RNAPII phosphates FCP1 complex. - Functional and biochemical characterization of interaction between Myc and p14ARF. - Physical and functional interaction between P-TEFb and Myc.

- Role of the BER, Base Excision Repair, enzymes in the Myc induced transcription.

- Epigenetics chromatin changes of Myc target genes.
- Role of LSD1 demethylase in Neuroblastoma.

- Genome-wide mapping of 8-oxodG in human and mouse cell line and its functional correlation with transcription and DNA replication.
- Bioinformatics tools required for the analyses of DIP-Seq, ChIP-Seq, GRO-Seq, RNA-Seq, etc.

Teaching activities

2011-2014,
Assistant Professor of Genetics and Molecular Human Genetics at University of Naples Federico II.

2015-2019, Professor of Genetics at University of Naples Federico II.

Commissions of trust
Reviewer panel member of:
- MIUR (Italy) for evaluation of GRANT (FIRB, PRIN, SIR)
- ANR (National Research Agency, France) for evaluation of Generic Call 2017 - Scientific Journal (BBA, Plos One, Oncotarget, PNAS).

Memberships of scientific societies Member of AGI and SIBBM

Prize

"Francesca Martini" Award - SIBBM 2016 "Frontiers in Molecular Biology" Naples, 16-18 June 2016

Major collaborations
Dr. Dominguez-Sola, D, Institute for Cancer Genetics, Columbia University di New York;
Dr. Ivan Dellino, Dr. Mario Faretta e Prof PierGiuseppe Pellicci, Campus-IFOM-IEO, Milano.
Prof. Irina Stepanov e Dr. Bin Ma, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA

  1. Majello B, Gorini F, Saccà CD, Amente S. Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer.Biochim Biophys Acta Gene Regul Mech. 2019 May;1862(5):535-546. doi: 10.1016/j.bbagrm.2019.03.004. Epub 2019 Apr 2.
  2. Amente S, Di Palo G, Scala G, Castrignanò T, Gorini F, Cocozza S, Moresano A, Pucci P, Ma B, Stepanov I, Lania L, Pelicci PG, Dellino GI, Majello B. Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells. Nucleic Acids Res. 2019 Jan 10;47(1):221-236.
  3. Amente S, Milazzo G, Sorrentino MC, Ambrosio S, Di Palo G, Lania L, Perini G, Majello B. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumour suppressor genes in neuroblastoma. 2015 Jun 10;6(16):14572-83. 


  4. Amente, L. Lania, B. Majello, The histone LSD1 demethylase in stemness and cancer transcription programs, Biochim Biophys Acta, May 16 (2013) S1874-9399(13)00094-1. 

  5. Amente, J. Zhang, M.L. Lavadera, L. Lania, E.V. Avvedimento, B. Majello, Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression, Nucleic Acids Res, 39 (2011) 9498-9507. 

  6. Amente, A. Bertoni, A. Morano, L. Lania, E.V. Avvedimento, B. Majello, LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription, Oncogene, 29 (2010) 3691- 3702. 

Tematiche di Ricerca
1.

Intertwined Roles of Transcription and DNA Damage

2.

Transcription Regulation
DNA Damage
DNA repair

Parole Chiave

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