Utente

Current position Full Professor of Genetics (Professore Ordinario) BIO/18 at Department of Biology University of Naples 'Federico II'. Head of an Human Genetics Laboratory.

Scientific Career

1985-1987 Post-doctoral fellow at the Department of Pathology, New York University Medical School, NY USA.
1991-1996 Researcher at the Department of Genetics and General Molecular Biology Universiy of Naples
1996-2010 Associate Professor in Genetics.
2010-today Full Professor in Genetics at Department of Biology University of Naples
2014-today Presidente of the degree in Biological Sciences University of Naples Federico II
2019-today Member of the Faculty of the PhD program in Computational and Quantitative Biology

Teaching

Coordinatore Laurea Triennale Biologia Università Federico II Napoli http://www.dipartimentodibiologia.unina.it/corsi-di-laurea/laurea-triennale-in-biologia/

Referente Innovazione Didattica Dipartimento di Biologia Federico II Napoli http://www.dipartimentodibiologia.unina.it/didattica-innovativa/

Referente Commissione Innovazione e Sperimentazione Didattica Scuola Politecnica e delle Scienze Di Base Università Federico II Napoli

Delegato del Rettore Università Federico II Napoli alla Didattica




Synopsis of current scientific interests
Keywords :DNA Damage-Transcription-Autophage-Epigenetics-Cancers

Mammalian cells that sustain genotoxic as well as oncogenic insults must involve defensive mechanisms that either arrest cell cycle progression or trigger an apoptotic program.
However, to discriminate between physiological and potentially harmful states, the defensive mechanisms must be finely tuned.
A complex and non-redundant molecular pathways have been described to enable cells to respond to a plethora of stressful stimuli. Thus, a number of molecular responders are called in action when cells are subjected to scenarios that negatively affect their normal homeostasis.
Studies on general and dedicated factors as well as signal transduction pathways that mediate the cellular response to different stimuli are the major topics of my research with particular emphasis on studies of the oxydative DNA damage, the role of autophagy and epigeneitc changes in DNA damage response and Cancers.